A randomised trial of COnventional care versus Radioablation (stereotactic body radiotherapy) for Extracranial oligometastases
The term oligometastases describes the concept of an intermediary state where cancer exists as a limited number of metastases before cells acquire the ability to metastasise more widely. It is hypothesised that successful eradication of disease at oligometastatic stage may improve survival outcomes and even cure for a select few.
The CORE trial investigates if adding SBRT to standard therapy improves survival outcomes, focusing on common primary tumour sites where oligometastatic disease is encountered: non‐small cell lung cancer (NSCLC), breast and prostate.
CORE is a phase II/III multi‐centre, non‐blinded, randomised controlled trial comparing standard of care (SOC) with or without SBRT for extra‐cranial metastases. The primary endpoint is Progression Free Survival (PFS).
The phase II component of CORE aims to demonstrate:
- Feasibility of randomised recruitment
- Deliverability of the study in an international multi‐centre setting
- SBRT activity based on PFS across the three tumour types.
If all three aims are achieved additional funding will be sought to roll the study into parallel tumour‐site specific phase III trials.
For more information contact Clinical Trials and Statistics Unit at The Institute of Cancer Research (ICR-CTSU), London, UK. COREemail@example.com